Antoniou J, Zukor DJ, Mwale F, Minarik W, Petit A, Huk OL. Lady Davis Institute for Medical Research, SMBD-Jewish General Hospital, 3755, Chemin de la Côte Ste-Catherine, Montréal, QC H3T 1E2, Canada. email@example.comBACKGROUND: Metal ion toxicity, metal hypersensitivity, and metal carcinogenicity are causes for concern for patients with metal-on-metal hip replacements. Thus, understanding the biological fate of metal ions, and consequently their long-term systemic effects, is of great interest to patients and surgeons alike. CONCLUSIONS: The blood metal ion levels in the hip resurfacing group were similar to those in the 28 and 36-mm-head metal-on-metal total hip arthroplasty groups. This study suggests that the increased metal ion levels had no effect on oxidative stress markers in the blood of these patients.