The blood thinner shots are really no big deal. They are subcutaneous – meaning the needle only goes right below the surface of the skin (much less painful than an intramuscular injection such as the flu shot). Most of the time you feel a little prick, but the whole routine takes less than 10 seconds. The needle is small, and the whole procedure is really simple. After my first HSR, under doctor’s orders, I was on aspirin to prevent blood clots, and I ended up with a DVT anyway. I had to do 14 days of Lovenox (comes in a pre-filled syringe) followed by six months of Coumadin. After my second HSR, I went on Lovenox immediately for the first 30 days (one shot per day) followed by 30 days of aspirin. I didn’t like injecting myself either, but since the medication potentially saved me from experiencing another DVT, I gladly took it for as long as my doctor wanted me to be on it. In fact, my doctor gave me a choice of whether I wanted to do the Lovenox for 30 days or Coumadin for 6 months after my second HSR. His preference was the Lovenox. When I was on the Coumadin after my first surgery, I had to have my blood drawn every 2-3 weeks to make sure that my clotting times were where they should be. Also, during that 6 month period, I was at increased risk for bleeding, so that not only did I bruise very easily, but even when I had a minor cut, I bled rather profusely.